Iron + folic acid, 30 tab

The vitamin-mineral complex of iron and folic acid is a drug that includes iron salts, folic acid and some vitamins (C, in 12) Designed to make up for iron deficiency in the body and have an antenemic effect.

The mechanism of action:
Iron is a component of hemoglobin, myoglobin and various enzymes. The total iron content in the body is about 50 mg/kg in men and 35 mg/kg in women. Approximately 60% of the iron is involved in the transfer of oxygen by red blood cells.
The daily need for iron is 12-20 mg/kg/day in men and 8-15 mg/kg/day in women. However, no more than 10% of iron is absorbed into the digestive tract. Food prevents the absorption of iron preparations, although it improves their tolerance.

Preparations, which are vitamin-mineral complexes, may include iron salts (iron gluconate, iron sulfate, iron hydroxide-polymaltous complex, iron fumarat), folic acid, a number of vitamins (C, 1, B 2, 2, 2, 2, 2, 2, 2, 2, 2 In 6, PP) They are designed to replenish the deficiency of iron in the body and have an antenemic effect.
Folic acid in these complexes helps to improve the clinical effect of drugs and enhances the absorption of iron ions.
In addition, folic acid is necessary for the normal ripening of megaloblasts and the formation of normoblasts, contributes to the stimulation of erythropoiesis, takes part in the synthesis of amino acids (glycine, methionine), nucleic acids, purines, pyrimidins, in the exchange of choline, histidine.
To restore iron reserves in macrophages, an adult patient should take iron drugs for at least 6 months. After 3-4 days. After the start of treatment, the content of reticulocytes increases. If an increase in the level of reticulocytes against the background of therapy is not observed, then the cause may consist of irregular administration of drugs, impaired iron absorption, prolonged bleeding, erroneous diagnosis or with concomitant diseases.

Pharmacokinetics:
After taking the drugs of this group, iron and folic acid are well absorbed from the gastrointestinal tract. The bioavailability of iron is 5-35% Iron is almost completely associated with plasma transfers and is involved in the process of the formation of hemoglobin, myoglobin, cytochromoxidase, catalase and peroxidase, or deposited in the tissues of the body in the form of ferritin. The binding of folic acid with plasma proteins is 64% Iron is excreted with feces, urine and then. Folic acid is excreted mainly by the kidneys, partially through the intestines.
Composition: in 1 tablet: vitamin S-80mg., Iron-14 mg., Folic acid-200 mg., Vitamin B12- 2.5 mg.
Method of application: adults and adolescents over 12 years old with latent iron deficiency, as well as for the prevention of iron and folic acid deficiency, are usually prescribed 1 tablet of the drug once a day. The duration of the preventive administration of the drug is 1-2 months.

Place in therapy:
Treatment and prevention of iron deficiency anemia of various etiologies (during pregnancy, with impaired iron absorption from the digestive tract, with prolonged bleeding, with inferior and unbalanced nutrition).

Contraindications:
hypersensitivity.
diseases accompanied by the accumulation of iron in the body (aplastic anemia, talassemia, hemosiderosis, hemochromatosis).
Violations of iron assimilation (siser -archery anemia, lead anemia, pernicious anemia (vitamin B 12 insufficiency).
Violation of iron recycling (sider -strob anemia, talassemia, lead intoxication, late skin porphyria).
Anemia not associated with a deficiency of iron or folic acid (hemolytic, megaloblastic).
side effects:
The feeling of overflowing the stomach.
Nausea.
vomiting.
constipation.
Jaraus.
staining the stool is dark.

Precautions:
Against the background of therapy with the drugs of this group, control of the levels of hemoglobin, hematocrit, the amount of reticulocytes, serum iron, the total iron -binding ability of serum, ferritin is required.

Interactions:
Antacids and tetracycline while using the drugs of this group worsen the absorption of iron