Folic acid 1000 μg, 50 tablets of 115 mg

For the prevention of hypovitaminosis, the most preferably balanced diet. Products rich in folic acid are green vegetables (salad, spinach, tomatoes, carrots), fresh liver, legumes, beets, eggs, cheese, nuts, cereals.
Folic acid is not used for treatment in 12 -deficiency (pernicious), normocytic and aplastic anemia, as well as refractory anemia.
with pernicious (in 12 -deficient) anemia folic acid, improving hematological indicators, masks neurological complications. Fernicial anemia, the prescription of folic acid in doses exceeding 0.1 mg/day is not yet excluded, is not recommended (exception - pregnancy and lactation).
It should be borne in mind that patients in hemodialysis need increased amounts of folic acid.
During treatment, antacids should be used 2 hours after taking folic acid, colorcuumin - 4-6 hours before or 1 hours after taking folic acid.
It should be borne in mind that antibiotics can distort (give obviously low indicators) the results of a microbiological assessment of the concentration of folic acid plasma and red blood cells.
When using large doses of folic acid, as well as therapy for a long period, a decrease in the concentration of vitamin B 12 is possible.
Pharmacological action
B vitamin B (vitamin B, vitamin B 9) can be synthesized by intestinal microflora.
In the body, folic acid is restored to tetrahydrofolyic acid, which is coenzym, which is involved in various metabolic processes.
It is necessary for the normal ripening of megaloblasts and the formation of normoblasts. It stimulates erythropoiesis, is involved in the synthesis of amino acids (including glycine, methionine), nucleic acids, purines, pyrimidins, in the exchange of choline, histidine.
Method of application and dosage
inside, after eating.
with a deficiency of folic acid-400 μg (1 table) On a day. For the prevention of the development of defects of the nervous tube in the fetus in the 1st trimester of pregnancy-400MKG-800 μg (1-2 tablets).
Interaction with other drugs
reduces the effect of phenytein (an increase in its dose is required).
Analgesics (prolonged therapy), anticonvulsants (including phenytoid and carbamazepine), estrogens, oral contraceptives increase the need for folic acid.
Antacids, collaces, sulfonamines (including sulfasalazine) reduce the absorption of folic acid.
Metretexate, pyrimetamine, triamteren, trimetrome inhibit dihydrofolateredustase and reduce the effect of folic acid (instead of it to patients using these drugs, mesh of fololinate should be prescribed).
With the simultaneous use with chloramphenicol, neomycin, polymixins, tetracycline, the absorption of folic acid decreases.
overdose
It can occur with prolonged use (more than 1-2 months) of folic acid in doses of more than 1000 μg per day and as a result of combined use with vitamin-mineral complexes.
side effects
Allergic reactions: skin rash, itching, bronchospasm, erythema, hyperthermia.
from the side of the gastrointestinal tract: nausea, bloating, bitterness in the mouth, anorexia. With prolonged use: hypovitaminosis in 12.
Composition
Composition: tablets - 1 tab.: Active substances: folic acid - 1 mg, excipients: lactose monohydrate - 93 mg, codovidon - 5 mg, silicon dioxide colloidal (Aerosil) - 0.5 mg, magnesium stearate - 0.5 mg50 PCS. in a polymer bank