Molecular cell mechanisms of peptidermic regulation of brain functions

Preparations used to treat the pathology of the brain, including old and senile people, belong to different pharmacological groups. Among them, antioxidants, nitrogen oxide blockers, substances that suppress the processes of lipid peroxidation, etc. are currently promising neuroprotectors, are short peptides with high physiological activity and lack of side effects. Is the monograph devoted to one of the new developments of the St. Petersburg Institute of Bioregulation and Gerontology? neuroprotective peptide Edr (Glu-SP-ARG) The results of the molecular cell aspects of the neuroprotective effects of the EDR peptide are generalized. It is noted that in the model of dissociated crops of neurons of the cerebral cortex of the rat peptide, EDR regulates the expression of signal molecules - markers of functional activity of cells? Serotonin and proapoptotic protein P53. In addition, it was shown that in the models of Alzheimer and Huntington Peptide, EDR restores the number of dendritic spectacles of neurons, which characterizes its ability to normalize interneuron interactions. The neuroprotective role of EDR peptide is manifested in experimental prenatal hypoxia and hyperhomocysteinemia. EDR peptide reduces the accumulation of active oxygen forms in neurons, increasing their resistance to oxidative stress and preventing the interaction of homocysteine ​​and its derivatives with glutamate receptors. The assumption is substantiated that the identified neuroprotective effects of the EDR peptide are associated with its ability to penetrate the core and nucleus of cells, to contact DNA or histone proteins and thus regulate the expression of genes and the synthesis of proteins that realize the functions of brain neurons. The oral use of the EDR peptide contributed to the regulation of the expression of the protein of thermal shock and increased physical activity and performance in athletes, and in the elderly, the elderly normalized memory and psycho -emotional state.
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