Ovarian cancer. Fundamental and clinical studies. Monograph
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The monograph is devoted to the analysis of modern ideas about the pathogenetic mechanisms of the development of ovarian cancer - one of the most important problems of modern clinical medicine. Particular attention is paid to the morphological and molecular genetic characteristics of the epithelial ovarian cancer. The issues of the origin of tumors with low (from serous cystoadenoma and border serous ovarian tumors) and high (from serous pipe intraepithelial carcinas) degree of malignancy are considered, their differences from both clinical and molecular genetic positions were analyzed. The detection of a mutation in the TR53 genus and its subtypes: with a loss or increased function of the ONCUPRESPEPRES of the P53, the wild type of TR53 with an increase in the function of the MDM2 protein, with an increase in the MDM2 protein, is recognized as promising for typical tumors and targeted treatment of patients with ovarian tumors.
The monograph also discusses the hereditary forms of ovarian cancer due to mutations in the BRCA1 and BRCA2 genes. The fundamental and clinical aspects of the study of matrix metalloproteinase and their tissue inhibitors, the system of insulin-like growth factors and their transport proteins, control points of immunity, panoramic proteomic analysis of blood plasma, microrm, circulating antibodies to glycans, as well as the possibility of practical use of molecular-genetic markens in the detailed use of molecular and genetic markers in the detailed. diagnosis, evaluating the metastatic potential and prognosis of ovarian cancer.
The section of the clinical course of ovarian cancer, modern capabilities and methods of surgical and drug treatment, including targeted drugs, is widely represented, and radiation therapy prospects are highlighted.
For oncologists, gynecologists, biologists and other specialists
The monograph also discusses the hereditary forms of ovarian cancer due to mutations in the BRCA1 and BRCA2 genes. The fundamental and clinical aspects of the study of matrix metalloproteinase and their tissue inhibitors, the system of insulin-like growth factors and their transport proteins, control points of immunity, panoramic proteomic analysis of blood plasma, microrm, circulating antibodies to glycans, as well as the possibility of practical use of molecular-genetic markens in the detailed use of molecular and genetic markers in the detailed. diagnosis, evaluating the metastatic potential and prognosis of ovarian cancer.
The section of the clinical course of ovarian cancer, modern capabilities and methods of surgical and drug treatment, including targeted drugs, is widely represented, and radiation therapy prospects are highlighted.
For oncologists, gynecologists, biologists and other specialists
Author:
Author:Gulyaeva Lyudmila Fedorovna, Nikolai Alekseevich Firekrubov, Stylidi Ivan Socratovich, Kushlinsky Nikolai Evgenievich
Cover:
Cover:Hard
Category:
- Category:Medical Books
Publication language:
Publication Language:Russian
Paper:
Paper:Completed
ISBN:
ISBN:978-5-6045698-9-4
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