HIV resistance to antiretroviral therapy

The book describes the mechanisms of the development of drug resistance in HIV-1 to the main classes of antiretroviral drugs and provides data on its prevalence among patients without experience of taking such drugs and in case of the ineffectiveness of antiretroviral therapy (ART) regimens. It discusses the current indications for prescribing ART and conducting a test for HIV resistance to antiretroviral drugs in clinical practice before starting ART and in case of the ineffectiveness of the ongoing ART, criteria and reasons for virological failure. The principles of managing patients with virological failure and the results of major studies on second-line ART regimens are outlined. It presents modern views on treatment adherence, basic definitions, and modern technologies for forming adherence for real clinical practice. It provides indicators of adherence risk and the technology for their detection and minimization. The book is intended for infectious disease specialists and physicians of other specialties who treat patients with HIV infection.