Depression and Resistance. Practical Guide

The principles of preventing the diagnosis and treatment of therapeutically resistant depression (TRD) are set out. The mechanisms for the formation of therapeutic resistance are described, the principles of its prevention are explained, the methods of differential diagnosis of resistant states of different types. Possible schemes of combining antidepressants of various groups are disassembled, the most well-known techniques of non-farmcological impact on the body in order to relocate resistant states. Features of the therapeutic approach to the treatment of TRD in patients with special categories (pregnant, nursing mothers, children and adolescents, elderly patients, patients with comorbid somatic pathologies) Addressable psychiatra, psychiatrists, narcologists, psychotherapists, neurologists, anesthesiologists-resuscitative and other specialists encountered with the treatment of mental illness, as well as patients and their relatives